TABLE 1.

The altered expression of marker genes for various brain cell types in the hippocampi of wild‐type and App^{NL−F/NL−F} mice fed an RD or HFD

Cell type	Marker gene	Relative expression (% RD‐fed wild‐type mice)
		HFD‐fed wild‐type	RD‐fed AppNL−F/NL−F	HFD‐fed AppNL−F/NL−F
Astrocyte	Aqp4	96.42	120.13	107.82
	Gfap	102.86	115.10	128.01
	Glul	99.98	107.68	108.20
	S100b	94.57	110.69	107.27
	Slc1a1	99.27	104.44	104.10
	Slc1a2	98.19	109.86	99.00
	Mean	98.55	111.32	109.07
	SD	2.88	5.57	9.90
Oligodendrocyte	Mag	112.78	103.41	124.33
	Mbp	107.55	108.34	111.51
	Mog	110.97	98.34	115.80
	Sox10	111.30	102.11	109.95
	Mean	110.65	103.05	115.40
	SD	2.21	4.13	6.45
Microglia	Aif1	100.60	98.21	94.12
	C1qa	121.59	130.97	139.62
	C1qb	116.39	120.24	132.32
	Cd68	128.68	145.24	165.39
	Itgam	98.89	96.71	104.91
	Lgals3	102.29	98.30	108.48
	Ptprc	117.32	108.44	145.07
	Mean	112.25	114.02	127.13
	SD	11.64	18.83	25.49
NSC/NPC	Ascl1	99.32	112.66	110.23
	Bmp4	111.59	127.28	160.18
	Dcx	105.75	119.54	96.37
	Egf	94.50	101.41	104.82
	Igf2	150.47	148.18	156.45
	Notch2	123.84	113.32	99.78
	Nr2e1	101.36	95.07	94.97
	Shh	110.79	104.09	109.80
	Sox2	98.13	106.47	94.87
	Mean	110.64	114.22	114.16
	SD	17.38	16.00	25.72
Neuron	Chga	95.33	101.57	103.23
	Eno2	92.32	92.81	93.68
	Nefh	88.86	103.59	91.82
	Nefl	92.69	100.71	100.92
	Nefm	88.67	110.27	99.87
	Rbfox3	94.75	90.48	93.11
	Snap25	94.34	102.92	100.44
	Syp	99.25	96.42	100.41
	Syt1	96.74	99.58	97.54
	Tubb2a	92.63	86.51	94.41
	Mean	93.56	98.49	97.54
	SD	2.95	8.61	2.69

Significantly altered genes vs. RD‐fed wild‐type mice (eBayes ANOVA: p < 0.05) are underlined.

Abbreviations: HFD, high‐fat diet; NPC, neural progenitor cell; NSC, neural stem cell; RD, regular diet.