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Proposed function mechanism of BmCPV-miR-1 and BmCPV-miR-3 on regulation of the target gene BmRan and on replication of BmCPV. BmCPV-miR-1 and BmCPV-miR-3 negatively regulate the translation of the BmRan protein, thus inhibit the transport of pre-miRNA from the nucleus to the cytoplasm in host cells, thereby the population of host miRNAs decreases, consequently creating a favorable intracellular environment for BmCPV genome replication and virus multiplication is enhanced.
