Table 1.

Clinical data and virulence factors of colistin resistant K. pneumoniae isolates

		Clinical data			Virulence factors
No	Strain number/protocol number	Diagnosis	Outcome	Antibiotic therapy	String test	Hemolysin production	Resistance to serum bactericidal activity
1	KC-4559	Tetraplegia, cardiorespiratory arrest	D	Meropenem, colistin	-	+	+
2	KC-5887	Amyotrophic lateral sclerosis, motor neuron disease	D	None	-	+	+
3	KC-5874	Cardiomyopathy, cor decompensatum	D	Meropenem, colistin	-	+	+
4	KC-5852	UTI, tetraparesis	S	Sulfamethoxazole/trimethoprim	-	+	+
5	KC-7985	UTI, kidney failure	S	Meropenem, colistin, linezolid	-	+	+
6	KC-5831	Chronic obstructive pulmonary disease	S	Amikacin	-	+	+
7	KC-7950	Subdural hematoma, hemiparesis	S	Meropenem, fosfomycin	-	+	+
8	KC-6730	Motor neuron disease	D	None	-	+	+
9	KC6396	NA	NA	NA	-	+	+
10	KC-7822	Multifocal motor neuropathy	S	Sulfamethoxazole/trimethoprim	-	+	+
11	KC-10844	Cerebrovascular insult, hemiparesis	S	Sulfamethoxazole/trimethoprim, amikacin	-	+	+
12	KC-9393	Cerebral glioblastoma	S	Sulfamethoxazole/trimethoprim	-	+	+
13	KC-10877	Cerebrovascular insult, UTI	S	None	-	+	+
14	KC-9644	Parkinson's disease, paraparesis	S	Sulfamethoxazole/trimethoprim	-	+	+
15	VG2803	NA	S	Meropenem	-	+	+
16	VG-3203	NA	S	Meropenem	-	+	+
17	KC-11559	Hemiparesis, UTI, urosepsis	S	Sulfamethoxazole/trimethoprim	-	+	+
18	KC-11366	Guillain–Barré syndrome	D	None	-	+	+
19	KC-8260	Cerebrovascular insult, hemiparesis	S	Levofloxacin	-	+	+
20	G-4229/18	UTI	S	Imipenem	-	+	+
21	G-33494	UTI	S	Ciprofloxacin	-	+	+
22	R-37876	Pneumonia, brain contusion	S	Amikacin, ceftazidime/avibactam	-	+	+
23	R-32246	Pleuropneumonia, cardiac arrest	D	Ceftazidime/avibactam	-	+	+
24	R-34003	Subdural hematoma, pneumonia	S	Ceftazidime/avibactam	-	+	+
25	R-48638	Bronchial neoplasm	S	Ceftazidime/avibactam	-	+	+
26	KC-14064	Subdural hematoma, hemiparesis	S	Meropenem	-	+	+
27	KC-13630	Pneumonia	S	Cefpodoxime	-	+	+
28	KC-13635	Cardiomyopathy, cardiorespiratory arrest	D	None	-	+	+
29	KC-13933	Intracerebral bleeding	D	None	-	+	+
30	KC-12390	NA	NA	NA	-	+	+
31	KC-13184	Bronchial cancer with cerebral metastasis	S	None	-	+	+
32	G-5376	UTI	S	None	-	+	+
33	SI-33057	Hepatic cirrhosis	D	Meropenem	-	+	+
34	SI-31419	NA	NA	NA	-	+	+
35	SI32324	Bowel perforation, septic shock	D	Amikacin	-	+	+
36	G-14029	Wound infection	S	Sulfamethoxazole/ trimethoprim	-	+	+
37	UG17233	Bilateral pneumonia Planocellular neoplasm	D	Meropenem, clindamycin	-	+	+
38	UG15750	UTI	S	None	-	+	+
39	UG16530	Decubital ulcer	S	Co-amoxiclav, clindamycin, vancomycin, amikacin	-	+	+
40	G-39684	UTI	S	Meropenem	-	+	+
41	G-6643/2-17	UTI	S	Sulfamethoxazole/ trimethoprim	-	+	+
42	SI-4-20	Necrotizing pancreatitis	S	Colistin, linezolid, ceftriaxone, metronidazole	-	+	+
43	DU-2721	Prostatitis	S	Sulfamethoxazole/ trimethoprim	-	-	+
44	DU-4076	Kidney stone	S	Sulfamethoxazole/ trimethoprim	-	-	+
45	UR3304	UTI	S	Ceftazidime/avibactam	+	-	+
46	DU-5321	Polytrauma	S	Amikacin Ceftazidime/avibactam	-	-	+

UTI – urinary tract infection; S – survived; D – died; NA – data not available; KC – Karlovac hospital; VG – Sestre Milosrdnice Hospital Zagreb; SI – Sisak Public Health Institute; G – Andrija Štampar Public Health Institute Zagreb; DU – Dubrovnik Public Health Institute; UR – urine specimen (Split University Hospital Centre); UG – urogenital specimen (Split University Hospital Centre); RI – Rijeka University Hospital Centre.