Figure.
Associations between top candidate single nucleotide polymorphisms (SNPs) and HDL-C (high-density lipoprotein cholesterol) and triglyceride (TG) concentrations stratified by category of sugar-sweetened beverages (SSB) intake in a random effects meta-analysis of the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) cohorts and the UK Biobank (UKB).A, In a random effects meta-analysis of the CHARGE cohorts and the UKB, the association of the minor allele at rs71556729 with HDL-C concentrations was observed only among the highest SSB consumers (β, 2.12 [95% CI, 1.16–3.07] mg/dL, P<0.0001) and not the lowest SSB consumers (P=0.81; PDiff<0.0001). B, In a random effects meta-analysis of the CHARGE cohorts and the UKB, the association of the minor allele at rs55673514 with TG concentrations was observed only among the highest SSB consumers (β, 0.06 [95% CI, 0.02–0.09]) ln-mg/dL, P=0.001), and not the lowest SSB consumers (P=0.84; PDiff <0.0005); linear regression models represent associations between each additional effect allele and HDL-C (mg/dL) or TG (ln-mg/dL) concentrations among SSB consumption categories accounting for family, population structure, and field center (where applicable) and adjusting for age, sex, total energy intake, education, smoking, physical activity, alcohol intake, and body mass index. Intake categories are different for the highest SSB consumers (CHARGE: >1 serving/d; UKB: SSB consumers) and lowest SSB consumers (CHARGE: <1 serving/mo; UKB: SSB nonconsumers) in the 2 samples.