Table 2.
Treatment | Oxidative stress markers in the hippocampus | ||||
---|---|---|---|---|---|
GSH (μmol/g) | MDA (mmol/g) | SOD (unit/min/g) | Nitrite (mmol/g) | Total protein (μg/ml) | |
DW + DW | 690.1 ± 48.3 | 17.1 ± 1.2 | 14.4 ± 0.8 | 144.1 ± 1.7 | 1751.3 ± 24.1 |
SCO + DW | 316.4 ± 18.9c | 64.6 ± 3.4c | 146.1 ± 14.3c | 532.4 ± 3.4c | 450.8 ± 13.2c |
SCO + DZ | 322.1 ± 23.5 | 27.0 ± 1.6∗∗∗ | 201.3 ± 19.4∗∗∗ | 320.9 ± 3.6∗∗∗ | 1289.5 ± 17.8∗∗∗ |
SCO + TA | 720.1 ± 85.6∗ | 40.5 ± 7.4∗∗∗ | 743.6 ± 34.9∗∗∗ | 409.2 ± 2.2∗∗∗ | 1176.2 ± 34.4∗∗∗ |
SCO + E29 | 561.9 ± 30.3∗ | 16.3 ± 1.3∗∗∗ | 191.1 ± 15.5∗∗∗ | 332.8 ± 2.2∗∗∗ | 1139.9 ± 39.3∗∗∗ |
SCO + E57 | 319.4 ± 11.5 | 17.9 ± 1.1∗∗∗ | 187.9 ± 10.8∗∗∗ | 331.2 ± 3.8∗∗∗ | 1352.3 ± 26.4∗∗∗ |
SCO + 114 | 544.3 ± 33.2∗ | 28.3 ± 1.8∗∗∗ | 260.4 ± 13.2∗∗∗ | 327.2 ± 2.6∗∗∗ | 1466.3 ± 21.1∗∗∗ |
Each value represents the average ± SEM; n = 7. cp < 0.001vs. normal control. ∗p < 0.05; ∗∗∗p < 0.001vs. negative control; DW: distilled water (10 ml/kg); SCO: scopolamine (1 mg/kg); DZ: donepezil (1.2 mg/kg); TA: tacrine (10 mg/kg); E29, E57, and E114: aqueous extract of Z. jujuba at respective doses of 29, 57, and 114 mg/kg. DW + DW: normal control group; SCO + DW: negative control group; SCO + DZ: positive control group treated with donepezil; SCO + TA: positive control group with tacrine; SCO + E29-E114: test groups treated with Z. jujuba extract; GSH: reduced glutathione; MDA: malondialdehyde; SOD: superoxide dismutase.