Table 3.
Treatment | Oxidative stress markers in the prefrontal cortex | ||||
---|---|---|---|---|---|
GSH (μmol/g) | MDA (mmol/g) | SOD (unit/min/g) | Nitrite (mmol/g) | Total protein (μg/ml) | |
DW + DW | 1134.1 ± 102.4 | 4.5 ± 0.5 | 61.3 ± 5.1 | 169.6 ± 1.7 | 2170.9 ± 36.1 |
SCO + DW | 232.6 ± 33.7c | 13.3 ± 2.3c | 212.6 ± 373.2c | 613.6 ± 2.8c | 331.6 ± 32.2c |
SCO + DZ | 487.3 ± 49.2 | 7.2 ± 2.6∗ | 126.5 ± 16.6∗∗∗ | 402.7 ± 2.4∗∗∗ | 1202.2 ± 33.9∗∗∗ |
SCO + TA | 720.9 ± 75.2∗∗ | 6.2 ± 1.1∗∗ | 59.4 ± 7.3∗∗∗ | 530.4 ± 3.2∗∗∗ | 1404.1 ± 25.1∗∗∗ |
SCO + E29 | 848.1 ± 87.9∗∗∗ | 9.5 ± 0.7 | 271.8 ± 24.1∗∗∗ | 370.4 ± 3.5∗∗∗ | 958.6 ± 28.4∗∗∗ |
SCO + E57 | 710.4 ± 79.9∗∗ | 9.5 ± 1.2 | 395.1 ± 48.3∗∗∗ | 366.4 ± 2.8∗∗∗ | 865.3 ± 26.7∗∗∗ |
SCO + 114 | 538.1 ± 56.9 | 5.3 ± 0.5∗∗ | 321.5 ± 27.5∗∗∗ | 425.2 ± 1.1∗∗∗ | 683.9 ± 32.4∗∗∗ |
Each value represents the average ± SEM; n = 7. cp < 0.001vs. normal control. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001vs. negative control; DW: distilled water (10 ml/kg); SCO: scopolamine (1 mg/kg); DZ: donepezil (1.2 mg/kg); TA: tacrine (10 mg/kg); E29, E57, and E114: aqueous extract of Z. jujuba at respective doses of 29, 57, and 114 mg/kg. DW + DW: normal control group; SCO + DW: negative control group; SCO + DZ: positive control group with donepezil; SCO + TA: positive control group treated with tacrine; SCO + E29-E114: test groups treated with Z. jujuba extract; GSH: reduced glutathione; MDA: malondialdehyde; SOD: superoxide dismutase.