Table 3.

Univariate and Multivariate Analyses for Overall Survival.

		Univariate Analysis		Multivariate Analysis
		Crude HR (95% CI)	P	Adjusted HR (95% CI)	P
Age at TRMN		1.03 (1.01–1.06)	0.008	1.03 (1.00–1.06)	0.03
First cancer	Breast cancer	1		1
	Gynecological cancer	2.17 (1.27–3.68)	0.004	0.97 (0.51–1.83)	0.9
Performance status	0–1	1		1
	2–3	4.27 (2.35–7.77)	<0.001	3.75 (2.04–6.91)	<0.001
Lindsley’s modified classifier	TP53/PPM1D	1		1
	MDS-like	0.52 (0.27–0.99)	0.045	0.51 (0.25–1.06)	0.1
	De novo/Pan-AML	0.28 (0.15–0.53)	<0.001	0.41 (0.20–0.82)	0.012
Number of treatment lines		1.19 (1.04–1.36)	0.013	1.16 (0.99–1.36)	0.1

Global logRank test P < 0.0001.

CI = confidence interval; TRMN = therapy-related myeloid neoplasm.