Characteristics of HA cases and GS score high cases. (A) Per-patient HRR alteration type analysis in HA and/or GS cases, following stratification by sex and TP53 mutation status. Numbers in parenthesis next to cancer types represent the number of cases in the four groups, respectively. (B) Comparisons of three gene expression–based HRD assessment scores after stratification by HA and GS. These scores were calculated from modification of the RPS, comparison between The Cancer Genome Atlas OV samples, and KEGG pathway database, respectively (see Methods). *P < .05, **P < .01, and ***P < .001 in the Mann-Whitney U test. GS, genomic scar; HA, HRR-altered; HRD, homologous recombination DNA repair deficiency; HRR, homologous recombination repair; rRPS, reversed Recombination Proficiency Score; OV, ovarian cancer.