Table 1.

Other small-molecule SARS-CoV-2 inhibitors with known crystal structures.

No.	Name	Structure	EC50 or IC50 (μM)	Target	PDB ID	Refs
1	Boceprevir		4.13	Mpro	6XQU	[150], [151], [152]
2	Calpain inhibitor XII		0.45	Mpro	6XFN	[89], [153], [154]
3	Calpeptin		1.56	Mpro	7AKU	[155]
4	Carmofur		1.82	Mpro	7BUY	[156], [157]
5	Ebselen		4.67	Mpro	7BAK	[158], [159]
6	GC-373		0.40	Mpro	6WTK	[160]
7	GC-376		0.030	Mpro	6WTJ	[89], [160], [161]
8	GRL0617		2.20	PLpro	7CMD	[19], [162], [163], [164]
9	GS-441524		0.70	RdRp	7BF6	[165], [90]
10	Isofloxythepin		4.80	Mpro	7AY7	[155]
11	Masitinib		2.50	PLpro	7JU7	[166], [167]
12	MI-23		0.0076	Mpro	7D3I	[168]
13	ML188		2.5	Mpro	7L0D	[146], [169]
14	MPI1		0.100	Mpro	7JPZ	[170]
15	MPI3		0.0085	Mpro	7JQ0	[170]
16	MPI4		0.015	Mpro	7JQ1	[170]
17	MPI5		0.033	Mpro	7JQ2	[170]
18	MPI6		0.060	Mpro	7JQ3	[170]
19	MPI7		0.047	Mpro	7JQ4	[170]
20	MPI8		0.105	Mpro	7JQ5	[170]
21	Narlaprevir		5.10	Mpro	6XQT	[150], [152]
22	N3		16.77	Mpro	6LU7	[73], [171]
23	Pelitinib		1.25	Mpro	7AXM	[155]
24	PF-00835231		0.13	Mpro	6XHM	[172]
25	Suramin		0.26	RdRp	7D4F	[173], [174]
26	Telaprevir		18.0	Mpro	6XQS	[150]
27	UAWJ246		0.045	Mpro	6XBG	[89]
28	UAWJ247		0.042	Mpro	6XA4	[89]
29	UAWJ248		0.012	Mpro	6XBI	[89]
30	VIR250		not reported	PLpro	6WUU	[27]
31	VIR251		not reported	PLpro	6WX4	[27]
32	5 h		4.2	Mpro	7JKV	[175]
33	11a		0.053	Mpro	6LZE	[75], [176]
34	11b		0.040	Mpro	6M0K	[75]
35	15 l		0.019	Mpro	7MBI	[177]
36	2		5.10	PLpro	7JIT	[19]
37	3		6.40	PLpro	7JIV	[19]
38	14		0.128	Mpro	7L12	[137]
39	21		0.018	Mpro	7L13	[137]
40	26		0.17	Mpro	7L14	[137]