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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Schizophr Res. 2021 Feb 23;234:87–93. doi: 10.1016/j.schres.2021.02.001

Figure 1. Structural complexity of the complement C4 gene.

Figure 1.

Panel A: C4 genes exist in four forms (1) C4A gene short (C4AS - no HERV insertion); (2) C4A gene long (C4AL – contains HERV insertion); (3) C4B gene short (C4BS no HERV insertion); (4) C4B gene long (C4BL – contains HERV insertion). Panel B: Five common C4 haplogroups that reflect copy number variation and presence/absence of the HERV insertion. This diagram is based on material from Sekar et al (2016)(Sekar et al., 2016).