Table 3.
Odds ratios for C4 haplogroup associations with biomarkers of pathogen exposures and gut dysbioses
| C. albicans IgG | CMVIgG | LBP | T. gondii IgG | |||||
|---|---|---|---|---|---|---|---|---|
| HTZ | HMZ | HTZ | HMZ | HTZ | HMZ | HTZ | HMZ | |
| Control | ||||||||
| AL-BS | NS | NS | NS | NS | NS | NS | NS | NS |
| AL-BL | NS | NS | NS | NS | NS | NS | NS | NS |
| BS | NS | NA | 0.52 (0.29–0.95) 0.02 |
NA | NS | NA | NS | NA |
| AL | NS | NA | NS | NA | NS | NA | NS | NA |
| AL-AL | NS | NA | NS | NA | NS | NA | NS | NA |
| Schizophrenia | ||||||||
| AL-BS | NS | NS | 0.62 (0.44–0.87) 0.001 |
0.62 (0.43–0.90) 0.001 |
NS | NS | NS | NS |
| AL-BL | NS | NS | NS | 1.79 (1.21–2.64) 0.008 |
0.97 (0.94–1.00) 0.002 |
NS | NS | NS |
| BS | 0.20 (0.05–0.82) 0.0001 |
NS | 1.55 (1.01–2.38) 0.0001 |
0.0003 (1E-6–0.10) 0.0001 |
NS | 1.18 (1.05–1.33) 0.0001 |
NS | 0.43 (0.26–0.70) 0.001 |
| AL | 2.16 (1.22–3.83) 0.0005 |
NS | 1.56 (1.09–2.24) 0.0001 |
0.20 (0.06–0.62) 0.0001 |
NS | 1.09 (1.02–1.16) 0.0001 |
NS | 0.33 (0.18–0.60) 0.0001 |
| AL-AL | NS | NS | NS | NS | 0.96 (0.92–0.99) 0.0001 |
NS | NS | 17.67 (0.98–319.19) 0.0001 |
OR – odds ratio; CI – confidence interval; p – p-value; HTZ – heterozygote; HMZ – homozygote; NS - not statistically significant at p<0.05; NA - not applicable (due to absence of homozygotes in the control group); CMV - cytomegalovirus
Comparison is HTZ and HMZ relative to absence of haplotype.