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Alveolar parenchymal α-SMA positivity is significantly reduced in severe asthma (SA) compared to controls, with COPD tending to show similar reductions. Representative α-SMA immunostained images (20X) from a control sample (A), a severe asthma sample (B), and a COPD sample (C). The average percent α-SMA positive pixels in each sample, quantified using the Aperio ImageScope-embedded algorithm. Data expressed as mean ± SD (D).
