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. Author manuscript; available in PMC: 2022 Apr 26.
Published in final edited form as: Menopause. 2021 Apr 26;28(8):883–892. doi: 10.1097/GME.0000000000001785

Table 2.

Association between previously-identified VMS SNPs and ever reporting high frequency VMS (yes/no) in SWAN

SNP CHR:POS GWAS
P-valuea
Gene Non-
effect
Effect White
(N=702)
Black
(N=306)
Chinese
(N=129)
Japanese
(N=129)
EAF OR Pvalue EAF OR P
value
EAF OR Pvalue EAF OR P
value
rs74827081 4:104556732 4.77E-15 TACR3 G C 0.05 0.49 0.0086 0.01 21.29 0.3484 0 NA NA 0 NA NA
rs74589515 4:104584258 7.11E-15 TACR3 T G 0.05 0.48 0.0079 0.01 42.45 0.3957 0 NA NA 0 NA NA
rs79246187 4:104580809 2.64E-14 TACR3 C T 0.05 0.48 0.0075 0.02 2.26 0.4688 0.0003 NA NA 0.0008 NA NA
rs112390256 4:104575473 2.81E-14 TACR3 G A 0.05 0.48 0.0072 0.04 1.58 0.4817 0 NA NA 0 NA NA
rs75544266 4:104584997 3.15E-14 TACR3 C T 0.05 0.48 0.0083 0.02 2.16 0.4943 0.0002 NA NA 0.0001 NA NA
rs78154848 4:104562840 5.65E-14 TACR3 T C 0.05 0.49 0.0076 0.02 2.29 0.4554 0 NA NA 0 NA NA
rs76643670 4:104562842 5.65E-14 TACR3 T A 0.05 0.49 0.0076 0.02 2.29 0.4554 0 NA NA 0 NA NA
rs78289784 4:104580155 6.55E-14 TACR3 C A 0.05 0.48 0.0076 0.02 2.25 0.4699 0 NA NA 0 NA NA
rs77322567 4:104569676 2.17E-12 TACR3 C A 0.05 0.48 0.0072 0.04 1.68 0.4189 0 NA NA 0 NA NA
rs78141901 4:104593977 7.27E-10 TACR3 C A 0.05 0.83 0.5060 0.01 0.66 0.7603 0 NA NA 0 NA NA
rs78844131 4:104600029 3.34E-09 TACR3 T G 0.05 0.82 0.4772 0.01 0.63 0.7309 0 NA NA 0 NA NA
rs79852843 4:104628587 4.38E-09 TACR3 T C 0.05 0.79 0.4081 0.01 0.61 0.7127 0 NA NA 0 NA NA
rs80328778 4:104612447 4.97E-09 TACR3 C T 0.05 0.80 0.4336 0.01 0.62 0.7230 0 NA NA 0 NA NA
rs112623956 4:104623714 6.19E-09 TACR3 A G 0.05 0.79 0.4126 0.01 0.61 0.7131 0 NA NA 0 NA NA
rs75699757a 11:56818268 1.60E-09 OR5BP1P A G 0.03 0.91 0.8923
rs11518608a 11:56767184 3.47E-08 NA G C 0.03 0.82 0.7730
rs148680409a 3:173330544 3.69E-08 NLGN1 G A 0.01 0.11 0.1446
a

GWAS p values are from the African American SHARe GWAS (6).

VMS: vasomotor symptoms; SNP, single nucleotide polymorphism; SWAN: Study of Women’s Health Across the Nation; EAF: Effect allele frequency; OR, odds ratio; NA, not applicable.