Table 2.
SNP | CHR:POS | GWAS P-valuea |
Gene | Non- effect |
Effect | White (N=702) |
Black (N=306) |
Chinese (N=129) |
Japanese (N=129) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EAF | OR | Pvalue | EAF | OR | P value |
EAF | OR | Pvalue | EAF | OR | P value |
||||||
rs74827081 | 4:104556732 | 4.77E-15 | TACR3 | G | C | 0.05 | 0.49 | 0.0086 | 0.01 | 21.29 | 0.3484 | 0 | NA | NA | 0 | NA | NA |
rs74589515 | 4:104584258 | 7.11E-15 | TACR3 | T | G | 0.05 | 0.48 | 0.0079 | 0.01 | 42.45 | 0.3957 | 0 | NA | NA | 0 | NA | NA |
rs79246187 | 4:104580809 | 2.64E-14 | TACR3 | C | T | 0.05 | 0.48 | 0.0075 | 0.02 | 2.26 | 0.4688 | 0.0003 | NA | NA | 0.0008 | NA | NA |
rs112390256 | 4:104575473 | 2.81E-14 | TACR3 | G | A | 0.05 | 0.48 | 0.0072 | 0.04 | 1.58 | 0.4817 | 0 | NA | NA | 0 | NA | NA |
rs75544266 | 4:104584997 | 3.15E-14 | TACR3 | C | T | 0.05 | 0.48 | 0.0083 | 0.02 | 2.16 | 0.4943 | 0.0002 | NA | NA | 0.0001 | NA | NA |
rs78154848 | 4:104562840 | 5.65E-14 | TACR3 | T | C | 0.05 | 0.49 | 0.0076 | 0.02 | 2.29 | 0.4554 | 0 | NA | NA | 0 | NA | NA |
rs76643670 | 4:104562842 | 5.65E-14 | TACR3 | T | A | 0.05 | 0.49 | 0.0076 | 0.02 | 2.29 | 0.4554 | 0 | NA | NA | 0 | NA | NA |
rs78289784 | 4:104580155 | 6.55E-14 | TACR3 | C | A | 0.05 | 0.48 | 0.0076 | 0.02 | 2.25 | 0.4699 | 0 | NA | NA | 0 | NA | NA |
rs77322567 | 4:104569676 | 2.17E-12 | TACR3 | C | A | 0.05 | 0.48 | 0.0072 | 0.04 | 1.68 | 0.4189 | 0 | NA | NA | 0 | NA | NA |
rs78141901 | 4:104593977 | 7.27E-10 | TACR3 | C | A | 0.05 | 0.83 | 0.5060 | 0.01 | 0.66 | 0.7603 | 0 | NA | NA | 0 | NA | NA |
rs78844131 | 4:104600029 | 3.34E-09 | TACR3 | T | G | 0.05 | 0.82 | 0.4772 | 0.01 | 0.63 | 0.7309 | 0 | NA | NA | 0 | NA | NA |
rs79852843 | 4:104628587 | 4.38E-09 | TACR3 | T | C | 0.05 | 0.79 | 0.4081 | 0.01 | 0.61 | 0.7127 | 0 | NA | NA | 0 | NA | NA |
rs80328778 | 4:104612447 | 4.97E-09 | TACR3 | C | T | 0.05 | 0.80 | 0.4336 | 0.01 | 0.62 | 0.7230 | 0 | NA | NA | 0 | NA | NA |
rs112623956 | 4:104623714 | 6.19E-09 | TACR3 | A | G | 0.05 | 0.79 | 0.4126 | 0.01 | 0.61 | 0.7131 | 0 | NA | NA | 0 | NA | NA |
rs75699757a | 11:56818268 | 1.60E-09 | OR5BP1P | A | G | 0.03 | 0.91 | 0.8923 | |||||||||
rs11518608a | 11:56767184 | 3.47E-08 | NA | G | C | 0.03 | 0.82 | 0.7730 | |||||||||
rs148680409a | 3:173330544 | 3.69E-08 | NLGN1 | G | A | 0.01 | 0.11 | 0.1446 |
GWAS p values are from the African American SHARe GWAS (6).
VMS: vasomotor symptoms; SNP, single nucleotide polymorphism; SWAN: Study of Women’s Health Across the Nation; EAF: Effect allele frequency; OR, odds ratio; NA, not applicable.