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. Author manuscript; available in PMC: 2022 Apr 26.
Published in final edited form as: Menopause. 2021 Apr 26;28(8):883–892. doi: 10.1097/GME.0000000000001785

Table 4.

Association between genetic risk factors and trajectories for any VMS in SWAN

Outcome Predictor White Black
N OR LL UL P value N OR LL UL P value
Early onset vs. low rs74827081a 187 0.57 0.20 1.65 0.30 57 NA NA NA NA
FMP onset vs. low 258 0.48 0.20 1.13 0.09 84 NA NA NA NA
High vs. low 197 0.55 0.20 1.51 0.25 128 NA NA NA NA
Early onset vs. low VMS PRS (“all SNPs”)b,c 432 1.21 0.89 1.65 0.23 205 0.79 0.44 1.44 0.44
FMP onset vs. low 0.96 0.73 1.25 0.74 0.79 0.46 1.36 0.39
High vs. low 1.13 0.83 1.53 0.44 0.75 0.45 1.22 0.24
Early onset vs. low Menarche PRS (“all SNPs”)b,d 428 0.83 0.60 1.14 0.24 205 1.10 0.59 2.06 0.75
FMP onset vs. low 0.75 0.58 0.98 0.03 0.74 0.43 1.30 0.30
High vs. low 0.77 0.57 1.05 0.10 0.55 0.34 0.91 0.02
Early onset vs. low Menopause PRS (“all SNPs”)b,e 432 1.18 0.86 1.61 0.31 205 0.93 0.51 1.72 0.83
FMP onset vs. low 1.00 0.76 1.31 0.99 0.72 0.42 1.22 0.22
High vs. low 1.04 0.77 1.42 0.79 0.77 0.48 1.25 0.29

All PRSs were standardized (mean=0, SD =1) within each race/ethnic group prior to analyses

a

Multiple independent logistic regression models were constructed to assess the odds of being in each VMS trajectory group compared to the “low” VMS trajectory group. When a category had a minor allele count < 5, logistic regression was not conducted and “NA” was reported.

b

Multinomial logistic regression model was constructed with the PRS as the predictor and VMS trajectories as the outcome using the “low” VMS trajectory as the reference group.

c

VMS “all SNPs” PRS was constructed using all available independent SNPs that were significant at p<10−4 in GWAS meta-analysis (6). Independent SNPs were selected using a clumping approach (LD r2 threshold = 0.5, distance from index SNP = 250kb).

d

Menarche “all SNPs” PRS was constructed using all available independent SNPs that were significant at p<10−4 in GWAS meta-analysis (23). Independent SNPs were selected using a clumping approach (LD r2 threshold = 0.5, distance from index SNP = 250kb).

e

Menopause “all SNPs” PRS was constructed using all available independent SNPs that were significant at p<10−4 in GWAS meta-analysis (22). Independent SNPs were selected using a clumping approach (LD r2 threshold = 0.5, distance from index SNP = 250kb).

VMS, vasomotor symptoms; PRS, polygenic risk score; SWAN: Study of Women’s Health Across the Nation; SNP, single nucleotide polymorphism; FMP, final menstrual cycle; OR, odds ratio; LL, lower limit of the 95% confidence interval; UL, upper limit of the 95% confidence interval; NA, not applicable.