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. 2021 Aug 19;54(10):2399–2416.e6. doi: 10.1016/j.immuni.2021.08.016

Figure 7.

Figure 7

Similarity of SARS2-38 epitope to other mAbs

(A) Structural comparison of SARS2-38 to selected mAbs targeting a similar region of the RBD. SARS2-38 heavy chain and light chain are colored royal blue and cyan, respectively. Antibodies 2-7 (PDB: 7LSS), REGN10987 (PDB: 6XDG), and S309 (PDB: 6WPS) are depicted with white light chains and dark gray heavy chains.

(B) Multiple sequence alignment of the SARS-CoV-2 RBD (residues 333–518) with mAb binding footprints as determined by PISA solvent exclusion analysis. The heavy chain, light chain, and shared contacts are shown in blue, cyan, and dark blue, respectively. Secondary structure annotation is displayed above the alignment in yellow, with ACE2 contacts designated by green triangles (Lan et al., 2020). VOC substitutions are designated below the alignment by red triangles and include residues from B.1.1.7, B.1.429, B.1.1.298, Wash-B.1.351, Wash-B.1.1.28, B.1.222, B.1.617.1, B.1.526+S477N, B.1.526+E484K, and B.1.617.2.