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Synthesis of 2-aminothiazole derivatives with phosphonomethoxymethyl linker: a) NaH, BrCH2P(O)(OiPr)2, RT; b) TFA, RT; c) TMSBr, pyridine, RT then (l)-NH2CH(Bn)COOiPr·HCl, Et3N, Aldrithiol-2, Ph3P, pyridine, 65 °C; d) Br2, CCl4, RT; e) PhB(OH)2, Pd(PPh3)4, Cs2CO3, dioxane, H2O, 80 °C.
