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Synthesis of 2-aminothiazole derivatives with phosphomethoxyethyl linker: a) Boc2O, TEA, THF, 50 °C; b) NaBH4, EtOH, RT; c) NaH, BrCH2P(O)(OiPr)2, RT; d) TFA, RT; e) TMSBr, pyridine, RT then (L)-NH2CH(Bn)COOiPr·HCl, Et3N, Aldrithiol-2, Ph3P, pyridine, 65 °C; f) Br2, CCl4, RT; g) RB(OH)2, Pd(PPh3)4, Cs2CO3, dioxane, H2O, 80 °C; h) thiophenol, CuI, phenantroline, Et3N, toluene, 110 °C.
