Scheme 4.
Synthesis of phosphonates 24–28 and phosphono diphosphates 29–33: a) TMSBr, pyridine, RT then DOWEX (50WX8 Na+); b) TBAH, 2 M aq. TEAB, MeOH, dioxane, RT; c) 1,1′-carbonyldiimidazole, DMSO, RT then (Bu3N)2P2O7, DMSO, RT.
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