Table 2: Performance Characteristics: Logistic Model of Diagnostic Claim Count, Refined Claims-Based Definition (Model 7), Overall and by Age Group.

The table is based primarily on the reconstructed sample, but Cross-Validation (CV) metrics are shown for the original (analytic) sample. Cross-validation was repeated with reconstructed sample for sensitivity analysis, which yielded similar results.

Mean: Mean value for performance characteristic from 1000 Monte Carlo resampling

Min: Minimum value for performance characteristic from 1000 Monte Carlo resampling

Max: Maximum value for performance characteristic from 1000 Monte Carlo resampling

Model	Clinician Adjudicated Dementia	Metric	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	CV AUC (0-1)	CV CITL (0-1)	CV Slope (0-1)
Overall	Freq: 2,854 Prev: 7.4%	Mean	68.0	93.5	77.1	90.1	0.94	0.00	0.97
		SD	1.8	0.7	2.0	0.5	-	-	-
		Min	60.8	91.3	70.7	88.1	-	-	-
		Max	73.7	95.6	83.4	91.6	-	-	-
Age 65-74	Freq: 412 Prev: 1.9%	Mean	56.6	98.0	75.2	95.6	0.90	0.00	0.81
		SD	3.8	0.5	5.2	0.4	-	-	-
		Min	45.0	96.1	58.8	94.4	-	-	-
		Max	67.5	99.2	89.3	96.6	-	-	-
Age 75-79	Freq: 477 Prev: 6.1%	Mean	60.9	93.6	73.1	89.4	0.88	−0.02	0.71
		SD	4.0	1.6	5.0	1.0	-	-	-
		Min	51.1	88.1	57.1	86.9	-	-	-
		Max	75.6	98.1	90.3	93.0	-	-	-
Age 80-84	Freq: 599 Prev: 11.1%	Mean	72.6	92.3	84.3	85.6	0.92	0.02	0.78
		SD	3.2	2.0	3.6	1.5	-	-	-
		Min	64.4	85.6	73.2	81.7	-	-	-
		Max	81.4	97.1	93.9	89.8	-	-	-
Age 85+	Freq: 1,366 Prev: 32.7%	Mean	74.6	72.4	75.8	71.1	0.88	0.00	0.84
		SD	3.5	4.4	3.1	3.2	-	-	-
		Min	62.5	59.2	67.8	62.3	-	-	-
		Max	86.4	86.8	87.3	82.6	-	-	-

Abbreviations

SD: Standard Deviation; PPV: Positive Predictive Value; NPV: Negative Predictive Value; 95%CI: 95% Confidence Interval; CV: 10-fold cross validation; CV AUC: 95% CI is Asymptotic Normal; Freq: Frequency; Prev: Prevalence; CV CITL: Calibration-in-the-large