Fig. 4.

Cariprazine, risperidone, and aripiprazole reversed VPA-induced social deficits in the social approach- avoidance test on postnatal day 59. (a) Cariprazine and risperidone increased time spent in the social chamber. (b) Cariprazine dose-dependently restored time spent with active social investigation of the stimulus rat; risperidone and aripiprazole also increased social activity. *, ** p<0.05, 0.01 vs VPA (Tukey’s multiple comparisons); †, †† p<0.05, 0.01 vs nonsocial (Tukey’s multiple comparisons); +, ++, +++ p<0.05, 0.01, 0.001 vs VPA (Dunnett’s multiple comparisons)