Figure 2.

In vivo chemical exchange saturation transfer (CEST) effects of 3TC. (A) Regional CEST effects were measured on hippocampus (HIP), cortex (CTX), piriform cortex (PIR), thalamus (TH) and hypothalamus (HY) (B) Representative Z-spectra on HIP of a control and a 3TC-treated mouse. (C) and (D) Representative fitted five Lorentzian functions of bulk water, aliphatic NOE, MT, amino and amide protons on HIP from a control and a 3TC-treated mouse. The sum of the fitted functions is also shown as fitted Z-spectrum. The Lorentzian functions are shown upside down. (E) The fitted NOE, amino and amide protons are shown for better visualization.