Figure 1.

Weighted Spearman correlations between the fraction of heterozygotes diagnosed with LQT2 in the literature or cohort and the listed features for each variant. Weighted Spearman correlations between the fraction of heterozygotes diagnosed with LQT2 in the literature and listed features for each variant. Black and red squares indicate the estimate for the weighted Spearman correlation, weighted by $1-\frac{1}{0.01+totalheterozygotes}$, for the literature and cohort dataset, respectively. The grey and red lines indicate 95% confidence intervals (obtained by bootstrap), respectively. Larger box sizes indicate greater number of variants included in calculation.