Table 4.

Demographic, clinical history and post-mortem findings of subjects with deleterious variation

Case	Age (yrs)	Sex	Race	Clinical vignette	Gross findings	Microscopic findings	Viral etiology
1	5	F	Hispanic	Found unresponsive in bed.	Acute angle RCA; enlarged tonsillar and adenoid tissue; obesity	Multifocal dense mononuclear inflammatory infiltrate (lymphocytes and plasma cells) with myocyte necrosis.	parvo (H)
2	9	F	E. Asian	Observed to be shaking; ventricular tachycardia.	Acute angle RCA	Multifocal dense mononuclear inflammatory infiltrate (predominantly lymphocytic) with myocyte necrosis.	N/A
3	9	F	White	Respiratory distress. Pulseless apneic when EMS arrived. Streptococcal infection with fever 10 days prior treated with Keflex. Vomiting and diarrhea for 1 month prior.	Normal	Multifocal dense mononuclear inflammatory infiltrate (lymphocytes and plasma cells with occasional eosinophils) with myocyte necrosis. Involvements of the pericardial and endocardial surfaces and AV node region.	N/A
4	12	F	Hispanic	Wide-complex VT to PEA arrest in ED. Had presented with abdominal pain, vomiting (diagnosed with gastritis), progressed to weakness of lower extremities, cough, running nose.	Slight myxomatous degeneration of mitral valve	Diffuse dense inflammatory infiltrate (lymphocytes and plasma cells) with microscopic foci of neutrophils and myocyte necrosis throughout myocardium. Inflammatory infiltrate most marked under epicardial surface.	N/A

H=heart; parvo= parvovirus B19; RCA= right coronary artery; VT= ventricular tachycardia; N/A = tissue not available for viral analysis; PEA= pulseless electrical activity; ED= emergency department