Skip to main content
. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Cancer Res. 2021 Jun 24;81(16):4275–4289. doi: 10.1158/0008-5472.CAN-21-0198

Figure 5. MAOA is essential for driving AR-dictated PC development and growth in mice.

Figure 5.

(A) Kaplan-Meier tumor-free curves of mice inoculated with LNCaP cells expressing a Dox-inducible MAOA shRNA and fed a Dox− or a Dox+ diet (n=40). (B) Tumor growth curves of mice fed a Dox− or a Dox+ diet in combination with the state of castration (Cx+) or not (Cx−) (n=5-10, which applies to C and D). (C, D) Tumor weights (C) and anatomic tumor images (D) at the endpoint. (E) ELISA of endpoint serum PSA levels (n=4-7). (F) qPCR of indicated genes in tumor samples (n=3). (G) Representative MAOA, Ki-67, cleaved caspase 3 (c-Cas3), AR and YAP1 IHC staining in tumor samples. Scale bars: 20 μm. (H) Quantification of % of Ki-67+ and c-Cas3+ cells in tumor samples (n=3). Data represent the mean ± SEM. *p<0.05, **p<0.01.