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. 2021 Aug 19;116:105274. doi: 10.1016/j.bioorg.2021.105274

Table 3.

Toxicity properties of the most promising compounds.

Compounds Rodent
Carcinogenicity
Ames Rat Oral
LD50
Aerobic Biodegradability
(4S,5R) Ephedroxane Non-Carcinogen 0.668916 0.991625 0.562176
(+)-Eudesma-4(15),
7(11)-dien-8-one
Non-Carcinogen 0.122225 2.38961 0.724887
Pachypodol1 Non-Carcinogen 0.669673 1.14754 0.481777
Pachypodol2 Non-Carcinogen 0.512067 0.866841 0.621833
Pachypodol3 Non-Carcinogen 0.599349 0.381132 0.490207
Pachypodol4 Non-Carcinogen 0.704909 0.393169 0.471899
Pachypodol5 Non-Carcinogen 0.577077 0.299591 0.616676
Pachypodol6 Non-Carcinogen 0.661746 0.452941 0.536422
Cirsiliol1 Non-Carcinogen 0.157938 0.24355 0.538137
Cirsiliol2 Non-Carcinogen 0.603944 0.220941 0.572221
Cirsiliol3 Non-Carcinogen 0.380653 0.133455 0.550077
Scoparone Non-Carcinogen 0.636048 1.14097 0.7564
Luteolin1 Non-Carcinogen 0.238779 0.194719 0.467705
Luteolin2 Non-Carcinogen 0.630162 0.149287 0.513354
Luteolin2Quercetin-3-
methyl ether
Non-Carcinogen 0.689358 0.163154 0.475555
Sesamin Non-Carcinogen 0.535598 0.489369 0.609635
Gallic acid Non-Carcinogen 0.687047 0.736671 0.404672
Anthraquinone Non-Carcinogen 0.776107 2.33633 0.171863
Glycyrrhetinic acid1 Non-Carcinogen 8.87E-06 1.27097 0.730006
Glycyrrhetinic acid2 Non-Carcinogen 8.87E-06 1.27097 0.730006