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. 2021 Aug 19;116:105274. doi: 10.1016/j.bioorg.2021.105274

Table 5.

All pharmacophores and their corresponding targets obtained by reverse finding target technology.

Pharmacophore Target(gene name) Efficacy
1tyr-01, 1tyr-01-s, 1tyr-02, 1tyr-02-s, 1tyr-03, 1tyr-03-s, 1tyr-04, 1tyr-05, 1tyr-05-s, 1tyr-06, 1tyr-06-s, 1tyr-07, 1tyr-08, 1tyr-08-s, 1tyr-09, 1tyr-09-s, 1tyr-10, 1tyr-10-s 1tyr(TTR) anti-inflammatory
1uk4-01,1uk4-02,1uk4-03,1uk4-04,1uk4-05,1uk4-06,1uk4-07, 1uk4-08, 1uk4-09, 1uk4-10 1uk4(rep) antiviral
2gz7-01, 2gz7-01-s, 2gz7-02, 2gz7-03, 2gz7-03-s, 2gz7-04, 2gz7-04-s, 2gz7-05, 2gz7-05-s, 2gz7-06, 2gz7-07, 2gz7-07-s, 2gz7-08, 2gz7-08-s, 2gz7-09 2gz7(rep) antiviral
2dq7-01, 2dq7-02, 2dq7-02-s, 2dq7-03, 2dq7-04, 2dq7-05, 2dq7-05-s, 2dq7-06, 2dq7-06-s, 2dq7-07, 2dq7-07-s, 2dq7-08, 2dq7-09, 2dq7-10 2dq7(FYN) anti-inflammatory
2x0v-01 2x0v(TP53) anti-inflammatory
2x0u-01 2x0u(TP53) anti-inflammatory
3cqu-01, 3cqu-01-s, 3cqu-02, 3cqu-02-s, 3cqu-03, 3cqu-03-s, 3cqu-04, 3cqu-04-s, 3cqu-05, 3cqu-05-s, 3cqu-06, 3cqu-06-s, 3cqu-07, 3cqu-07-s, 3cqu-08, 3cqu-08-s, 3cqu-09, 3cqu-09-s, 3cqu-10, 3cqu-10-s 3cqu(AKT1) antiviral, anti-inflammatory
3cqw-01, 3cqw-02, 3cqw-03, 3cqw-04, 3cqw-05, 3cqw-06, 3cqw-06-s, 3cqw-07, 3cqw-08, 3cqw-09, 3cqw-10, 3cqw-10-s 3cqw(AKT1) antiviral, anti-inflammatory