Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 18;11:16727. doi: 10.1038/s41598-021-96076-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

DINAH model transcriptome in NAFLD non-tumour identifies inflammatory pathways, macrophages and CD44 associated with HCC development. The RNA-seq transcriptome heat map, generated after unsupervised clustering analysis of non-tumour (NT) C3H/He, compares the two distinct groups identified (A), where G2 distinguished mice bearing greater number and size of tumours. Ingenuity pathway analysis (IPA) of the differentially expressed (DE) genes identified top canonical pathways ranked according to the-log adjusted p-value, or top diseases and bio-functions activation score (B). Gene Set Enrichment Analysis (GSEA) highlighted and inflammatory response signatures, the Macrophage enriched metabolic network, NF-κB and JAK/STAT3 pathways (C) as enriched in G2 mice. Considering the top IPA upstream regulators of the non-tumour G2-G1 transcriptomic profile, CD44 was ranked third among activated regulators (red) and was the one with the highest differential expression (DE) (blue) (D). Key: NES—normalised enrichment score; FDR—false discovery rate adjusted value; FWER—family-wise error rate.