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. 2021 Aug 18;11:16767. doi: 10.1038/s41598-021-96184-z

Figure 2.

Figure 2

GDF-7, IL-10 and PAP stabilise the Treg markers. The concentration dependent effects on FOXP3 and CTLA4 protein expression induced by GDF-7, IL-10 and PAP are shown in (A,B) for GDF-7; (C,D) for IL-10; and (E,F) for PAP. The effect on FOXP3 and CTLA4 expression was normalized to % activity as compared to the MFI of live cells treated with the on-plate PBS neutral controls. These proteins were tested in human Treg cells from multiple donors (Donor 1 filled circle ●, Donor 2 empty circle ○, Donor 3 empty square □ for wild type PAP, Donor 3 filled square ■ for catalytic dead mutant PAP [H12A]).