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. 2021 Aug 18;11:16767. doi: 10.1038/s41598-021-96184-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IFNα-4, IFNα-10 and IFNα-14 destabilise Treg markers whereas IFNα-7 stabilises CTLA4 expression. (A) Heatmap over mean effect on CTLA4 protein expression, (B) heatmap over mean effect on FOXP3 protein expression, (C) Heatmap over mean effect on cell viability, (D–E) Effect of IFNα-10 treatment on CTLA4 and FOXP3 expression, (F–G) Effect of IFNα-7 treatment on CTLA4 and FOXP3 expression. Tregs were from multiple donors (Donor 1 filled circle ●, Donor 2 empty circle ○, Donor 3 empty square □). The effect on FOXP3 and CTLA4 expression was normalized to % activity as compared to the MFI of live cells treated with the on-plate PBS neutral controls.