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. 2021 Aug 18;7:76. doi: 10.1038/s41531-021-00210-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Representative whole-cell current-clamp recordings of spontaneously active naive (a, top, black) and α-syn-overexpressing (b, top pink) dopaminergic neurons during sulpiride (D2 antagonist, 5 μM) bath application. a, b (Bottom) Distribution of raw ISIs in naive (a, bottom) and α-syn-overexpressing (b, bottom) dopaminergic neurons (Kolmogorov–Smirnov test, D = 0.13114, p < 0.001). c–e The bar graph shows firing frequency (c), interspike interval (ISI) (d), and firing regularity (e) during bath application of sulpiride (5 μM), revealing D2 antagonism in naive dopaminergic neurons promotes firing rates, interspike intervals, and regularity comparable to neurons overexpressing α-syn (n = 8 from three independent biological replicates, two-tailed unpaired t test, firing frequency: 100 ± 22.94 naive vs. 158.8 ± 30.37 α-syn-overexpressing neurons, p = 0.148; ISI: 100 ± 14.51 naive vs. 68.15 ± 11.84 α-syn-overexpressing neurons, p = 0.1147; CV of ISI: 100 ± 17.02 naive vs. 85.94 ± 6.599 α-syn-overexpressing neurons, p = 0.456).