Table 1.
Queensland Genomics’ Clinical projects.
| Disease areas | Description | Project type | Recruiting sites | Duration | |
|---|---|---|---|---|---|
| Demonstration Projects (Discovery Round) | Melanoma | A genomic approach for screening of patients at high risk of melanoma | Demonstration | PAH | 2017–2018 |
| Lung cancer | Bring modern genomics to the management of lung cancer in Queensland | Demonstration | PAH, TSHHS | 2017–2018 | |
| Mature onset diabetes in the young (MODY) | Evaluation of targeted genetic testing of MODY in gestational diabetes | Demonstration | Mater | 2017–2018 | |
| Hospital-acquired infections | Whole-genome sequencing to track, treat and prevent nosocomial infections | Demonstration | RBWH, PAH | 2017–2018 | |
| Cancer Portfolio (Strategy & Legacy Rounds) | Myeloid cancer | Improving the survival of children and adults with myeloid cancers | Implementation | RBWH, QCH, SR | 2019–2021 |
| Breast cancer | Q-IMPROvE: Implementation of precision oncology in breast cancer | Innovation | RBWH, Mater, PAH, TSHHS | 2020–2021 | |
| Haematology | Comprehensive risk stratification of acute leukaemias by targeted RNA sequencing | Implementation | RBWH, SR | 2020–2021 | |
| Whole-of-Life Portfolio (Strategy & Legacy Rounds) | Epilepsy | Improving diagnosis and treatment for refractory epilepsy | Implementation | MNHHS, QCH, CHHHS | 2019–2021 |
| Rare diseases | Rapid testing for paediatric intensive care patients | Innovation | QCH, RBWH, SR | 2019–2020 | |
| Cardiac genetics | Implementation of cardiac genetics clinics across Queensland | Implementation | TPCH, PAH, CHHHS | 2020–2021 | |
| Rare neuro-developmental disorders | Supporting diagnostic access for rare neurodevelopmental and complex multisystem disorders across Queensland | Implementation (via Incubator process) | QCH, MHHS, TSHHS, SR | 2020–2021 | |
| Paediatric immunology | Implementation of genomics into an integrated diagnostic and treatment service for primary immune deficiencies and other immune dysregulation syndromes in children | Implementation (via Incubator process) | QCH, SR | 2020–2021 | |
| Infectious Diseases (Strategy & Legacy Rounds) | Hospital-acquired infections | Whole-genome sequencing to track, treat and prevent nosocomial infections | Implementation | RBWH, PAH | 2019–2021 |
| Sepsis pathogens | Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens | Innovation | QCH, RBWH, TPCH, PAH | 2019–2021 | |
| Pathogen genomics | Rapid diagnostics that can rule in/out causes of sepsis, rule in/out antibiotic-resistant disease and detect rare or emerging infectious diseases in North Queensland (regional area) | Innovation | TSHHS, CHHHS | 2019–2020 |
CHHHS Cairns and Hinterland Hospital and Health Services, MHHS Mackay Hospital and Health Services, MNHHS Metro North Hospital and Health Services, PAH Princes Alexandra Hospital, QCH Queensland Children’s Hospital, RBWH Royal Brisbane and Women’s Hospital, SR Statewide recruitment, THHS Townsville Hospital and Health Services, TPCH The Prince Charles Hospital.