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. 2021 Aug 18;11:16724. doi: 10.1038/s41598-021-96138-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association between VO₂max and brain measures. The figure shows the clusters were a statistically significant association was detected between VO₂max and (a) GMBF and (b) CT, respectively. (a) VO₂max was negatively associated with GMBF of the left hippocampus (p FEW-corr = .0003, t = 5.64, MNI coordinates (x, y, z): −36, −34, 4). (b) VO₂max was, on the other hand, positively associated with the CT of the left superior temporal gyrus (STG) (p FWE-corr = .006, t = 5.18, MNI coordinates (x, y, z): −56, −21, −3). Clusters were superimposed on a surface rendering in SPM12. The Harvard–Oxford Cortical Structural Atlas was used to derive the location of the coordinates.