Fig. 5. An example case (PDBID: 2xvsA [10.2210/pdb2XVS/pdb]) for which C-QUARK failed to generate a correct fold.

a The native structure with a dashed circle highlighting the regions (40–43 and 51–52) which should be a 3₁₀-helix and beta-strand, respectively. However, the secondary structure predictor, PSSpred, predicted these regions as coils. b The best in the top five models from C-QUARK with the dashed circle marking the coil region that was not folded correctly due to the wrong SSE prediction. c The contact-maps for the native structure (gray circles), C-QUARK model (blue) and sequence-based predictions (red), where the rectangles highlight the above-mentioned region which has no predicted contacts.