Table 2.
The consistency of RT-PCR and pathological examination in detecting aberrant methylation of the SHOX2, RASSF1A, and PTGER4 gene.
| PCR (SHOX2 + RASSF1A + PTGER4) | Pathological examination | Total | |
|---|---|---|---|
| Positive | Negative | ||
| Positive | 134 | 4 | 138 |
| Negative | 20 | 193 | 213 |
| Total | 154 | 197 | 351 |
| AUC | 0.938 | ||
| 95%CI | 0.907–0.961 | ||
| Kappa | 0.86 | ||
| Sensitivity | 87.0% | ||
| Specificity | 98.0% | ||
| Positive predictive value (PPV) | 51.7% (cancer prevalence of 2.4%) | ||
| Negative predictive value (NPV) | 99.7% (cancer prevalence of 2.4%) | ||
SHOX2 Short stature homeobox 2 gene, RASSF1A Ras association domain family 1A gene, PTGER4 Prostaglandin E receptor 4 gene, AUC Area under the curve.