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. 2021 Aug 18;11:16797. doi: 10.1038/s41598-021-96224-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MGF-AuNPs preferentially accumulate in spleens of SCID mice: (A) Biodistribution of MGF-¹⁹⁸AuNPs in normal mice showing selective uptake only in liver and spleen and limited/no uptake in non-target organs; (B) Biodistribution of MGF-AuNPs in prostate tumor bearing SCID mice. Gold concentrations in tumor, liver and spleen measured using neutron activation analysis (NAA)—showing limited uptake in tumors and major uptake in spleen and liver—suggesting targeting of MGF-AuNPs on splenic macrophages.