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Canonical inflammasome signaling in cancer immunology. (A) GSDMC-dependent inflammasome signaling and pyroptosis pathway. (B) Granzyme A/B-mediated cytotoxic lymphocyte killing mechanism and GSDMB/GSDMD/GSDME induce tumor cell pyroptosis. (C) GSDMs-mediated inflammasome activation and pyroptosis regulate antitumor immunity.
