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. 2021 Aug 5;12:710110. doi: 10.3389/fimmu.2021.710110

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Copyright © 2021 Li, Lv, Shi, Feng, Liu, Gan, Wu, Fan and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NETosis elicited by noncanonical inflammasome signaling promotes tumorigenesis. (A) Various stimuli promote the release of NE from the granules, and NE cleaves and activates GSDMD, leading to nuclear and plasma membrane rupture and neutrophil cell lysis by NETosis. (B) Tumor-secreted ligands induce extrusion of NETs, and NETs protect tumor cells from CTL and NK cytotoxicity. The extracellular NETs-DNA binds to the transmembrane protein CCDC25 on tumor cells, and thus improve tumor cell migration.