Table 1.

Canonical and non-canonical Inflammasomes.

	Sensor proteins	Adaptor - Caspase	Activated caspases	Cleaved proteins	Cytokine release	Cell death
Canonical inflammasomes	NLRP family	adaptor protein ASC - caspase-1	caspase-1	GSDMD, pro-IL-1β, pro-IL-18	IL-1β, IL-18	pyroptosis; apoptosis;
	AIM2
	IFI16
	RIG-I
	NAIP-NLRC4	caspase-1
Non-canonical Inflammasomes	NLRP family	caspase-11	caspase-1, 11	GSDMD, pro-IL-1α, pro-IL-1β, pro-IL-18	IL-1α, IL-1β, IL-18	pyroptosis; apoptosis; necroptosis
	ZBP1 dependent - NLRP3	caspase-8, 6
	Inhibition of TAK1 or IkappaB kinase (IKK)	caspase-8
		TAK1 dependent - caspase-8	caspase-8