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. 2021 Aug 19;18(10):2325–2333. doi: 10.1038/s41423-021-00750-4

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© The Author(s) 2021

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Fig. 1 — Key features of exhausted CD8⁺ T cells. Exhausted CD8⁺ T cells are characterized by a loss of effector functions, sustained expression of inhibitory receptors, altered transcriptional and epigenetic landscape, and metabolic reprogramming