Table 2.
Na+ and Ca2+ ion channel regulation functions of SARS-CoV-2 S protein
| Domain | Alias | Motif | Start | End |
|---|---|---|---|---|
| LCN-type CS-alpha/beta | A | YYHKNNKSWMESEFR | 144 | 158 |
| B | ELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSC | 1202 | 1243 | |
| RyR | α1 | VYYHKNNKSWMESEFRVY | 143 | 160 |
| α2 | VYAWNRKRI | 350 | 358 | |
| β1 | FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPRE | 1052 | 1092 | |
| β2 | QELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHY | 1201 | 1272 | |
| B30.2/SPRY | β1 | CHDGKAHFPRE | 1082 | 1092 |
| β2 | YEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCC | 1206 | 1248 | |
| Ion_trans | α1 | WFHAIHVSGTNGTKRFDNPVLPF | 64 | 86 |
| α2 | VCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREF | 130 | 192 | |
| α3 | RGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAW | 403 | 436 | |
| α4 | GAEHVNNSYECDIPIGAGIC | 652 | 671 | |
| β1 | DCTMYICG | 737 | 744 | |
| β2 | WTFGAGAALQIPFAMQMAYRF | 886 | 906 | |
| β3 | SANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLH | 1021 | 1064 | |
| β4 | PAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTD | 1069 | 1118 | |
| β5 | ESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHY | 1195 | 1272 |