TABLE 1.

Summary of ferroptosis inhibitors that have been applicated in AD.

Reagent	Target	Study models	Conclusions	References
Deferoxamine (DFO)	Iron	Human cancer cells	DFO inhibited erastin-induced ROS accumulation and cell death	Dixon et al., 2012
Desferrioxamine (DFE)	Iron	Clinical patients	DFE slowed the clinical progression of the dementia associated with AD	Mclachlan et al., 1991
Clioquinol	Iron	Mouse model	Clioquinol prevented Tau deficiency impaired iron export	Lei et al., 2012
α-Lipoic acid (LA)	Iron	Mouse model	Effectively rescued tauopathy and cognitive impairment in P301S mice	Zhang Y. et al., 2018
Ferrostatin-1(Fer-1) Liproxstatin-1(Lip-1)	Lipid peroxidation	Primary neurons Mouse model	Fer-1/Lip-1 effectively ameliorate Aβ induced neuronal death and memory loss	Bao et al., 2021
Vitamin E	Lipid peroxidation	Clinical patients	Vitamin E slowed cognitive decline in patients with mild to moderate AD	Dysken et al., 2014
N-acetylcysteine (NAC)	Lipid peroxidation	Mouse model	Attenuated spatial memory deficits and synaptic plasticity loss in AD mice	More et al., 2018
Coenzyme Q10 (CoQ10)	Lipid peroxidation	Mouse model	Improved AD-Type behavioral and pathological symptoms in APP/PS1 mice	Muthukumaran et al., 2018
Selenium (Se)	Gpx4	Mouse model	Improved cognitive impairment and AD -related pathological symptoms in mice	Zhang Z. et al., 2018