Figure 1.

Decreased social interaction in female Foxp2^+/– mice in the 3-chambered task. Compared to control mice, female Foxp2^+/– mice show a significant decrease in time spent in the presence of a social cue (mouse; p = 0.0004, Foxp2^+/– n = 13, ctr n = 12), with a correspondingly significant increase in time spent in the presence of a non-social object (wire cup; p = 0.01) (A). In contrast, male Foxp2^+/– mice showed no significant changes in time spent in social or non-social interactions compared to control (p = 0.89, Foxp2^+/– n = 13, ctr n = 12) (B). When directly comparing male and female Foxp2^+/– mice, a significant decrease was observed in social interaction in females compared to males, with no change in non-social interaction (C; p** ≤ 0.01; p*** ≤ 0.001).