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. 2021 Aug 5;12:719602. doi: 10.3389/fphar.2021.719602

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Copyright © 2021 Jang, Hwang, Yang, Ryuk, Kim and Ha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WEMA slowed OVX-induced bone loss in mice. The mice were orally administered vehicle or WEMA for 5 weeks. (A) µ-CT images, BMD, and bone morphometric parameters of femoral trabecular bone. (B) Body weight gain and uterine weight. OVX, ovariectomy group; WEMA-L, OVX + WEMA 100 mg/kg/day treatment group; WEMA-H, OVX + WEMA 300 mg/kg/day treatment group; BMD, bone mineral density; BV/TV, bone volume per tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness. Tb. Sp, trabecular separation; *p < 0.05, **p < 0.01 versus the OVX group.