Figure 3.
H2 induces the release of Ghrelin from the walls of the stomach, depending on the β1-adrenergic receptor.
Note: (A) Drinking water saturated with, H2 for 4 days, increases the release of ghrelin to plasma in mice. An intraperitoneal injection of a competitive inhibitor of the β1-adrenergic receptor, Atenolol (10 mg/kg) blocks the increase in ghrelin levels caused by hydrogen water. Data are expressed as mean ± SD. *P < 0.05, vs. control group; #P < 0.05, vs. H2 group. (B) A diagram of the release of ghrelin when drinking water saturated with H2. The data are adapted from Noda et al.65 GHSR-1a: Growth hormone secretagogue receptor-1a; H2: molecular hydrogen.