. Author manuscript; available in PMC: 2021 Aug 19.

Published in final edited form as: ACS Chem Neurosci. 2021 May 5;12(10):1777–1790. doi: 10.1021/acschemneuro.0c00810

Table 1.

The AUC, C_max and T_max of 30 mg PO OXY, 10 mg PO DZP and 1 mg/kg DZP. SD is standard deviation and all units are shown in parenthesis.

Dosing Strategy		AUC (SD) (ng·h/mL)	C_max (SD) (ng/mL)	T_max (SD) (h)
OXY PO 30 mg (0–24 h)	Observed 1^a	268.2 (60.7)	39.3 (14.0)	2.6 (3)
	Observed 2^a	277.0 (89.6)	48.5 (15.9)	1.5 (NA)
	Predicted	311.83 (150.67)	38.0 (14.69)	1.2 (0.31)
DZP PO 10 mg (0–12 h)	Observed^b	1530 (464.33)	317 (89.55)	1.32 (0.56)
DZP PO 10 mg (0–12 h)	Predicted	1677.12 (434.66)	221.89 (51.5)	1.15 (0.35)
DZP IV 0.1 mg/kg (0–24 h)	Observed^c	2198.5 (NA)	NA	NA
DZP IV 0.1 mg/kg (0–24 h)	Predicted	1932.46 (582.83)	NA	NA

^a:

Observed 1 and Observed 2 are the experimental data collected from Drugs.com (https://www.drugs.com).

^{b, c:}

Observed data for PO and IV DZP are respectively obtained from two reports.^{70, 71}