Skip to main content
. Author manuscript; available in PMC: 2021 Aug 19.
Published in final edited form as: ACS Chem Neurosci. 2021 May 5;12(10):1777–1790. doi: 10.1021/acschemneuro.0c00810

Table 2.

The AUC ratio and Cmax ratio of the DDI profiles for PO OXY and 10 mg, 100 mg and 500 mg and 1000 mg of PO/IV DZP. CI is the 95% Confidence Interval. AUC24h ratio is the exposure of AUC ratio from the time 0 to 24 hours.

Dosing Strategy Formulation AUC24h ratio CI [5%,95%] Cmax ratio CI [5%,95%]
OXY 30 mg + DZP 10mg PO 1.01 [1.00,1.01] 1.01 [1.00,1.01]
IV 1.00 [1.00,1.01] 1.00 [1.00,1.00]
OXY 30 mg + DZP 100mg PO 1.05 [1.03,1.07] 1.04 [1.02,1.06]
IV 1.03 [1.02,1.05] 1.02 [1.01,1.04]
OXY 30 mg + DZP 500mg PO 1.13 [1.09,1.19] 1.09 [1.06,1.14]
IV 1.12 [1.07,1.17] 1.07 [1.04,1.12]
OXY 30 mg + DZP 1000mg PO 1.20 [1.12,1.29] 1.12 [1.07,1.19]
IV 1.18 [1.18,1.27] 1.10 [1.05,1.17]