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. Author manuscript; available in PMC: 2021 Aug 19.
Published in final edited form as: ACS Chem Neurosci. 2021 May 5;12(10):1777–1790. doi: 10.1021/acschemneuro.0c00810

Table 3.

The AUC ratio and Cmax ratio of the DDI profiles for PO OXY and 10 mg, 100 mg, 500 mg and 1000 mg of PO DZP when applying mixed-type inhibition to the DDI model. CI is the 95% Confidence Interval. AUC24h ratio is the exposure of AUC ratio from the time 0 to 24 hours.

Dosing Strategy AUC24h ratio CI [5%,95%] Cmax ratio CI [5%,95%]
OXY 30 mg + DZP 10mg 1.01 [1.01,1.02] 1.01 [1.00,1.02]
OXY 30 mg + DZP 100mg 1.07 [1.04,1.09] 1.04 [1.03,1.06]
OXY 30 mg + DZP 500mg 1.21 [1.13,1.31] 1.10 [1.06,1.16]
OXY 30 mg + DZP 1000mg 1.30 [1.17,1.48] 1.13 [1.07,1.22]