Table 3. Sensitivity of Each Modality According to Breast Densities and Study Groups.

Group and modality	Cancers, No. (%) [95% CI]		P value
	Dense breastsa	Nondense breastsa
Intervention group (n = 9705)
Screen-detected cancers (n = 68)
Mammography positive, ultrasonography positive or negative, CBE positive or negative	24 (54.6) [39.8-69.3]	20 (69.0) [52.1-85.8]	.20
Mammography positive or negative, ultrasonography positive, CBE positive or negative	29 (65.9) [51.9-79.9]	15 (51.7) [33.5-69.9]	.22
Mammography positive, ultrasonography positive, CBE positive or negative	12 (27.3) [14.1-40.3]	8 (27.6) [11.3-43.9]	.98
Mammography positive or negative, US positive or negative, CBE positive	10 (22.7) [10.3-35.1]	10 (34.5) [17.2-51.8]	.28
Only mammography positive	12 (27.3) [14.1-40.3]	12 (41.4) [23.5-59.3]	.21
Only ultrasonography positive	17 (38.6) [24.3-53.0]	7 (24.1) [8.6-39.7]	.18
Only CBE positive	0 (NA)	0 (NA)	NA
Any positive	41 (93.2) [85.7-100.0]	27 (93.1) [83.9-102.3]	.98
Interval cancers (n = 5), all modalities negative	3 (NA)	2 (NA)	NA
Control group (n = 9508)
Screen-detected cancers (n = 38)
Mammography positive, CBE positive or negative	22 (64.7) [48.6-80.8]	14 (60.9) [40.9-80.8]	.77
Mammography positive or negative, CBE positive	9 (26.5) [11.6-41.3]	6 (26.1) [8.1-44.0]	.97
Only mammography positive	15 (44.1) [27.3-60.8]	8 (34.8) [15.3-54.3]	.48
Only CBE positive	2 (NA)	0 (NA)	NA
Either mammography or CBE positive	24 (70.6) [55.3-85.9]	14 (60.9) [40.9-80.8]	.45
Interval cancers (n = 19), all modalities negative	10 (NA)	9 (NA)	NA

Abbreviations: CBE, clinical breast examination; NA, not applicable.

^aThe 2 least dense categories (almost entirely fatty and scattered fibroglandular tissues) are referred to as nondense, and the 2 most dense categories (heterogeneously dense and extremely dense) are referred to as dense.