Table 4. Clinical Stage and Histological Findings of Screen-Detected Cancers and Interval Cancers According to Breast Density.
| Patients, No. (%)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Intervention group | Control group | ||||||||
| Screen-detected cancers (n = 68) | Interval cancers (n = 5) | Screen-detected cancers (n = 38) | Interval cancers (n = 19) | ||||||
| Any modality positive (n = 68) | Only mammography positive (n = 24) | Only US positive (n = 24) | Only CBE positive (n = 0) | Either positive (n = 38) | Only mammography positive (n = 23) | Only CBE positive (n = 2) | |||
| Extremely and heterogeneously denseb | |||||||||
| Breast cancers, No. | 41 | 12 | 17 | 0 | 3 | 24 | 15 | 2 | 10 |
| Clinical stagec | |||||||||
| 0 and I | 35 (85.4) | 12 (100) | 2 (76.5) | 0 | 1 (33.3) | 19 (79.2) | 15 (100) | 1 (50) | 9 (90) |
| II or higher | 6 (14.6) | 0 | 4 (23.5) | 0 | 2 (66.7) | 5 (20.8) | 0 | 1 (50) | 1 (10) |
| Histopathological cancer type | |||||||||
| Noninvasived | 13 (31.7) | 7 (58.3) | 3 (17.7) | 0 | 0 | 6 (25) | 6 (40) | 0 | 3 (30) |
| Invasivee | 28 (68.3) | 5 (41.7) | 14 (82.4) | 0 | 3 (100) | 18 (75) | 9 (60) | 2 (100) | 7 (70) |
| Size of invasive tumors on histological examination, mm | |||||||||
| <10 | 11 (39.3) | 5 (100) | 4 (28.6) | 0 | 1 (33.3) | 9 (50) | 6 (66.7) | 1 (50) | 1 (14.3) |
| 11-20 | 15 (53.6) | 0 | 8 (57.1) | 0 | 0 | 4 (22.2) | 2 (22.2) | 1 (50) | 4 (57.1) |
| >20 | 2 (7.1) | 0 | 2 (14.3) | 0 | 2 (66.7) | 4 (22.2) | 0 | 0 | 0 |
| Data missing | 0 | 0 | 0 | 0 | 0 | 1 (5.6) | 1 (11.1) | 0 | 2 (28.6) |
| Node status of invasive cancers | |||||||||
| Negative | 23 (82.1) | 5 (100) | 11 (78.6) | 0 | 1 (33.3) | 15 (83.3) | 8 (88.9) | 2 (100) | 6 (85.7) |
| Positive | 5 (17.9) | 0 | 3 (21.4) | 0 | 2 (66.7) | 2 (11.1) | 0 | 0 | 0 |
| Data missing | 0 | 0 | 0 | 0 | 0 | 1 (5.6) | 1 (11.1) | 0 | 1 (14.3) |
| Scattered fibroglandular tissue and almost entirely fattyb | |||||||||
| Breast cancers, No. | 27 | 12 | 7 | 0 | 2 | 14 | 8 | 0 | 9 |
| Clinical stagec | |||||||||
| 0 and I | 24 (88.9) | 11 (91.7) | 6 (86.7) | 0 | 1 (50) | 9 (64.3) | 5 (62.5) | 0 | 9 (100) |
| II or higher | 3 (11.1) | 1 (8.3) | 1 (14.3) | 0 | 1 (50) | 5 (35.7) | 3 (37.5) | 0 | 0 |
| Histopathological cancer type | |||||||||
| Noninvasived | 13 (48.2) | 9 (75) | 1 (14.3) | 0 | 0 | 3 (21.4) | 3 (37.5) | 0 | 2 (22.2) |
| Invasivee | 14 (51.9) | 3 (25) | 6 (85.7) | 0 | 2 (100) | 11 (78.6) | 5 (62.5) | 0 | 7 (77.8) |
| Size of invasive tumors on histological examination, mm | |||||||||
| ≤10 | 5 (35.7) | 0 | 4 (66.7) | 0 | 1 (50) | 4 (36.4) | 3 (60) | 0 | 2 (28.6) |
| 11-20 | 9 (64.3) | 3 (100) | 2 (33.3) | 0 | 0 | 5 (45.5) | 1 (20) | 0 | 4 (57.1) |
| >20 | 0 | 0 | 0 | 0 | 1 (50) | 2 (18.2) | 1 (20) | 0 | 0 |
| Data missing | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (14.3) |
| Node status of invasive cancers | |||||||||
| Negative | 11 (78.6) | 2 (66.7) | 5 (83.3) | 0 | 2 (100) | 6 (54.6) | 3 (60) | 0 | 6 (85.7) |
| Positive | 3 (21.4) | 1 (33.3) | 1 (16.7) | 0 | 0 | 5 (45.5) | 2 (40) | 0 | 0 |
| Data missing | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (14.3) |
Abbreviations: CBE, clinical breast examination; US, ultrasonography.
a
Percentages might not total 100% because of rounding.
b
No cancer was found in the category of almost entirely fatty.
c
Based on the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision.
d
Includes ductal carcinoma in situ and lobular carcinoma in situ.
e
Includes invasive ductal carcinoma and special type.