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. 2021 Aug 5;12:708695. doi: 10.3389/fphys.2021.708695

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Copyright © 2021 Zinghirino, Pappalardo, Messina, Nicosia, De Pinto and Guarino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TFBS distribution on human and mouse VDAC promoters. The sequences of human and the promoter of mouse VDAC genes were analyzed by using JASPAR (http://jaspar.genereg.net/) and UniBind (https://unibind.uio.no/) databases, and the results were overlapped to find the most relevant TF families. A comparative analysis of common and unique TFBSs for each individual VDAC isoform of human and mouse was performed. Venn diagrams showed the number of common and unique TFBS clusters between human and mouse genes in (A) VDAC1, (B) VDAC2, and (C) VDAC3 promoters. (D) The results of the common TFBS families obtained from the comparative analysis of VDAC isoforms for each species were overlain to obtain the most evolutionarily conserved transcription factor families between a human and a mouse. In the Table, the Matrix family and the description of the main TFBS families shared among the three isoforms in both species are reported.